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Oral glutathione appears safe in the short term, but long-term safety data remains limited, and intravenous forms have been associated with adverse effects

Notably, in contrast to 23 (HA08), a structurally very similar epimer (HA09) which differs only with regard to one stereogenic center and exhibiting a 100-fold lower affinity to IRAP did not affect spine morphology, indicating a correlation between the capacity to inhibit IRAP and a positive impact on DSD and spine morphology

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